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大黃素

分析標(biāo)準(zhǔn)品,HPLC≥98%

Emodin

CAS號(hào)：518-82-1

分子式：C15H10O5

分子量：270.24

MDL：MFCD00001207

產(chǎn)品介紹

熔點(diǎn)：255℃

沸點(diǎn)：586.9℃ at 760 mmHg

外觀：橙黃色長針狀結(jié)晶(丙tong中結(jié)晶為橙色,甲醇中結(jié)晶為黃色)

溶解性：幾乎不溶于水，溶于乙醇及堿溶液。

敏感性：對(duì)光和空氣敏感

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(151篇)

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131. [IF=4.3] Chenghao Zhang et al."Emodin nanocrystals enhanced mucus penetration and ameliorated bleomycin-induced pulmonary fibrosis by pulmonary delivery."JOURNAL OF DRUG TARGETING.

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129. [IF=6.6] Wenyu Zhang et al."Biomimetic Iron-Based Nanoparticles Remodel Immunosuppressive Tumor Microenvironment for Metabolic Immunotherapy."International Journal of Nanomedicine.

128. [IF=4.9] Xiaoran Zhao et al."Constructing a hydrogel based on self-assembly properties of glycyrrhizic acid: A drug delivery system with digestive tract responsive."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Sep;697:134497

127. [IF=8.5] Guangfu Feng et al."Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy.."Research.2024 Sep;7:0464-0464

126. [IF=1.3] Ze-Ye Tan et al."Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.

125. [IF=3.9] Xiong Weijian et al."Emodin inhibits M1 macrophage activation that related to acute and chronic kidney injury through EGFR/MAPK pathway."FUNCTIONAL & INTEGRATIVE GENOMICS.2024 Aug;24(4):1-13

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123. [IF=10.6] Hou Yu et al."Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation."JOURNAL OF NANOBIOTECHNOLOGY.2024 Dec;22(1):1-21

122. [IF=7.9] Huiyi Song et al."Emodin nanocapsules inhibit acute pancreatitis by regulating lipid metabolic reprogramming in macrophage polarization."PHYTOMEDICINE".2024 Jul;130:155763

121. [IF=3.9] Yibao Wei et al."Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study."EXPERIMENTAL GERONTOLOGY".2024 Jun;190:112413

120. [IF=2] Lin Zhou et al."Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota."BIOLOGICAL & PHARMACEUTICAL BULLETIN".2024 Mar;47(3):680-691

119. [IF=5.6] Tong Qingheng et al."Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS."Frontiers in Pharmacology".2024 Mar;15:

118. [IF=7.5] Yong-Guang Liu et al."Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury."BIOMEDICINE & PHARMACOTHERAPY".2024 May;174:116456

117. [IF=3.1] Liuxuan Yang et al."Biomimetic delivery of emodin via macrophage membrane-coated UiO-66-NH2 nanoparticles for acute pancreatitis treatment."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS".2024 Apr;702:149649

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114. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216

113. [IF=2.7] Ding-Wen Cheng et al."Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice."Experimental and Therapeutic Medicine.2024 Jan;27(1):1-7

112. [IF=8.2] Yanli Wang et al."β-1,3-d-glucan particles-based “nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Dec;:128818

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110. [IF=4.8] Yan Lan et al."Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway."Drug Design Development and Therapy.

109. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

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104. [IF=10.2] Lei Fenting et al."Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19

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101. [IF=7.3] Li Chen et al."Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via Nur77-mediated epigenetic regulation of GLS1."BRITISH JOURNAL OF PHARMACOLOGY.2023 Jun;:

100. [IF=8.2] Jia Wan et al."Chitosan-based double network hydrogel loading herbal small molecule for accelerating wound healing."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Aug;246:125610

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97. [IF=3.242] Xu Chenyu et al."The active compound in Rheum officinale Baill, aloe-emodin promotes tomato seedling growth."PLANT GROWTH REGULATION.2023 Mar;:1-14

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94. [IF=3.37] Dingwen Cheng et al."Emodin Alleviates Arthritis Pain through Reducing Spinal Inflammation and Oxidative Stress."Molecular Pain.

93. [IF=6.656] Chong Chen et al."Yishen-Qingli-Huoxue Formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling."PHYTOMEDICINE.2022 Nov;:154546

92. [IF=3.571] Lin Zhou et al."Comprehensive investigation on the metabolism of emodin both in vivo and in vitro."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Jan;223:115122

91. [IF=3.614] Li Ji et al."Characterization of the chemical constituents and metabolic profile of Polygonum cuspidatum Sieb. et Zucc. in rat plasma, urine, and feces by ultra-high performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrom

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87. [IF=4.432] Yanqing Wang et al.Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.Eur J Pharmacol. 2021 Nov;:174603

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82. [IF=2.161] Jinjing Li et al."Enhanced hydrophilicity and antifouling performance of PES-C/emodin ultrafiltration membrane:."High Perform Polym. 0;():

81. [IF=2.401] Yongqian  Huang et al."The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection."Neurol Res. 2021;43(4):307-313

80. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

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74. [IF=3.943] Yuanyuan Liu et al."Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation."Int Immunopharmacol. 2020 Nov;88:106855

73. [IF=4.092] Shen  Pan et al."Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway."Inflammation. 2021 Aug;:1-14

72. [IF=4.142] Wang  Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4

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67. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711

66. [IF=5.81] Zhang N et al."Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).."Front Pharmacol. 2020 Jan;11:622046-622046

65. [IF=6.165] Neng Qiu et al."Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties."J Mol Liq. 2019 Sep;289:111151

64. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051

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62. [IF=1.843] Ma  Libin et al."Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2."Int Urol Nephrol. 2018 Feb;50(2):373-382

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60. [IF=3.366] Wu  Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

59. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56

58. [IF=4.366] Longfei Lin et al."Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses."Cells-Basel. 2019 Mar;8(3):263

57. [IF=4.411] Yanling Zeng et al."Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination."Molecules. 2018 May;23(5):1155

56. [IF=4.743] Hua  Jun-yi et al."Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats."Exp Mol Med. 2015 Jun;47(6):e170-e170

55. [IF=5.64] Wu  Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

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52.  Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

51.  Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

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44.  Wang, Qi, et al. "Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum." Scientific reports 7.1 (2017): 1-9.

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